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Promoting hepcidin synthesis is also a novel therapeutic approach for regulating iron metabolism abnormalities, which can be achieved by inhibiting the expression of transmembrane protease serine 6 (TMPRSS6)

54 In addition, increased Nox activity has been observed in different animal models of hypertension including ATII infusion, 14, 55, 56 deoxycorticosterone acetate (DOCA)-salt hypertension, 57 renovascular hypertension 58 and in spontaneously hypertensive rats

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